What is c erb b2?

C-erbB2, also known as HER2 (Human epidermal growth factor receptor 2) is a gene that encodes for a protein receptor found on the surface of certain cells. The protein is a member of the epidermal growth factor receptor family and plays a key role in regulating cell growth and survival.

Abnormal amplification, overexpression, or mutation of the C-erbB2 gene can lead to the development of various cancers, including breast, ovarian, lung, gastric and colorectal cancer. HER2-positive breast cancer is characterized by an overexpression of the HER2 protein receptor, making it a potential target for a specific type of cancer therapy called HER2-targeted therapy.

Testing for HER2 status is an important part of the diagnostic process for certain types of cancer, as it can help with treatment decisions and predicting patient outcomes. HER2-targeted therapies, including trastuzumab and pertuzumab, have significantly improved survival outcomes for HER2-positive breast cancer patients.